History:
Na+/K+-ATPase was discovered by Jens Christian Skou in 1957 while working as assistant professor at the Department of Physiology, University of Aarhus, Denmark. He published his work that year.In 1997, he received one-half of the Nobel Prize in Chemistry "for the first discovery of an ion-transporting enzyme, Na+/ K+-ATPase."
Function:
Export of sodium from the cell provides the driving force for several secondary active transporters , which import glucose, amino acids, and other nutrients into the cell by use of the sodium gradient.
Failure of the Na+-K+ pumps can result in swelling of the cell. A cell's osmolarity is the sum of the concentrations of the various ion species and many proteins and other organic compounds inside the cell. When this is higher than the osmolarity outside of the cell, water flows into the cell through osmosis. This can cause the cell to swell up and die (the lyse). The Na+-K+
pump helps to maintain the right concentrations of ions. Furthermore,
when the cell begins to swell, this automatically activates the Na+-K+ pump.
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| http://www.asso-etud.unige.ch/aecb/articles/notes_cours/1ere/biolobarja2011.pdf |
prof premraj pushpakaran writes -- 2018 marks the 100th birth year of Jens Christian Skou!!
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